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IGF-1 LR3 is a modified IGF-1 analog engineered with an arginine substitution at position 3 and a 13-amino-acid N-terminal extension

Those hexapeptides released GH through a mechanism distinct from GHRH, which implied a separate, then-uncharacterized receptor and, ultimately, a separate natural ligand

Spermidine synthase is encoded by the SRM gene (also known as SPDSY) which is located on chromosome 1p36.22 and is composed of 8 exons that encode a protein of 302 amino acids

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In metabolic and nutritional regulation, the GH/IGF-1 system responds dynamically to nutrient status and metabolic signals